科研综述

陈焕春及其团队率先确定了猪伪狂犬病在中国的爆发流行，阐明了中国猪伪狂犬病的五大临床症状，研制了疫苗，提出了中国伪狂犬病的根除计划。截至2011年7月，他及其团队克隆、测序了100余株病毒和30余种细菌的全基因组序列。构建了伪狂犬病毒、猪胸膜肺炎放线杆菌和猪沙门氏菌等3种通用型载体，研制了20余种基因工程疫苗和10余种分子诊断试剂盒。截至2019年3月，他主持国家自然科学基金、973、863、国家支撑计划等重大科研课题50余项，研制出30余种基因工程疫苗和分子诊断试剂盒，获得了19个转基因安全证书、24个新兽药注册证书、49个发明专利、国家重点新产品证书5项，在中国国内外期刊发表论文600余篇，SCI收录200余篇，出版专著3部，参编3部

部分论文

Ding Z, An K, Xie LL, Wu W, Zhang RX, Wang D, Fang Y, Chen HC, Xiao SB, Fang LR*. Transmissible gastroenteritis virus infection induces NF-kappa B activation through RLR-mediated signaling. Virology. 2017, 507: 170-178 3.354

He W, Zhao ZK, Anees A, Li YC, Ashraf U, Chen Z, Song YF, Chen HC, Cao SB, Ye J*. p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammationin Astrocytes. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3

Zheng Chengkun, Zhao Xigong, Zeng Ting, Cao Manman, Xu Jiali, Shi Guolin, Li Jinquan, Chen Huanchun, Bei Weicheng*. Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS microbiology letters.2017, 7 1.7649

Sun X, Wang SY, Lin X , Zhao LZ, Zhang D, Yi CY, Sun XM, Chen HC, Jin ML*.Proteome analysis of Duck Tembusu virus (DTMUV)-infected BHK-21 cells.Proteomics.2017, 17:12 4.041

Xu Jiali, Zheng Chengkun, Cao Manman, Zeng Ting, Zhao Xigong, Shi Guolin, Chen Huanchun, Bei Weicheng*.The manganese efflux system MntE contributes to the virulence of Streptococcus suis serotype 2.Microbial pathogenesis.2017, 110:23-30 2.009

Wang X, Wu CX, Song XR, Chen HC, Liu ZF*. Comparison of pseudorabies virus China reference strain with emerging variants reveals independent virus evolution within specific geographic regions.Virology. 2017, (506): 92-98 3.354

Qian Suhong, Fan Wenchun, Liu Tingting, Wu Mengge, Zhang Huawei, Cui Xiaofang, Zhou Yun, Hu Junjie, Wei Shaozhong, Chen Huanchun, Li Xiangmin*, Qian Ping. Seneca Valley Virus suppresses host type I interferon production by targeting adaptor proteins MAVS TRIF and TANK for cleavage. Journal of virology.2017, 4 Journal of virology 3.354

Wang SY, Sun X, Yi CY, Zhang D, Lin X, Sun XM, Chen HC, Jin ML*. AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300.Frontiers In Cellular And Infection Microbiology.2017, 7 4.3

Rasheed MA, Qi JJ, Zhu XF, He CF, Menghwar H, Khan FA, Gang Z, Zubair M, Hu CM, Chen YY, Chen HC, Guo AZ*. Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3

Wang Y, Li JT, Zhang AD, Zhu WF, Zhang Q, Xu ZM, Yan SX, Sun XM, Chen HC, Jin ML*. iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae. Journal Of Proteomics.2017, 160: 28-37 3.914

Zou Z, Huang K, Wei YM, Chen HC, Liu ZD, Jin ML*. Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection. Scientific Reports.2017, 7 4.259

Peng Z, Liang W, Liu WJ, Chen HC, Wu B*.Genome characterization of Pasteurella multocida subspecies septica and comparison with Pasteurella multocida subspecies multocida and gallicida. Archives Of Microbiology.2017, 199(4): 635-640 1.6

Ye Jing, Chen Zheng, Li Yunchuan, Zhao Zikai, He Wen, Zohaib Ali, Song Yunfeng, Deng Chenglin, Zhang Bo, Chen Huanchun, Cao Shengbo*.Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappaB. Journal of virology.2017, 91:8 3.354

Zhou YR, Fang LR, Wang D, Cai KM, Chen HC, Xiao SB*. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Stress Granule Formation Depending on Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) in MARC-145 Cells. Frontiers In Cellular And Infection Microbiology.2017, 7 4.3

Zhang Shishuo, Wang Ruifang, Su Huijuan, Wang Biaoxiong, Sizhu Suolang, Lei Zhixin, Jin Meilin, Chen Huanchun, Cao Jiyue, Zhou Hongbo*. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS Respectively. International journal of molecular sciences.2017, 18:4 3.226

出版专著

科研项目

科研奖项

人才培养

指导学生

截至2019年3月，陈焕春已培养毕业博士95人，硕士112人。

教学成果奖励

2005年9月1日，在项目动物医学专业人才培养方案的改革与实践中，获得 高等教育国家级教学成果奖二等奖。

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