谢晓亮编辑

中国科学院院士、美国科学院外籍院士、第十四届全国政协常委、生物物理化学家、北京大学李兆基讲席教授

谢晓亮

谢晓亮（Xiaoliang Sunney Xie），男，汉族，1962年出生于中国北京，中国科学院院士、美国科学院外籍院士，生物物理化学家，曾任哈佛大学化学与化学生物系终身教授、Mallinckrodt讲席教授，北京大学李兆基讲席教授，北京大学理学部主任，北京昌平实验室主任，第十四届全国政协委员、常委、教科卫体委员会委员。谢晓亮于1980年考入北京大学化学系；1990年从加州大学圣地亚哥分校博士毕业后进入芝加哥大学从事博士后研究；1992年进入美国太平洋西北国家实验室工作；1999年被聘为哈佛大学化学与化学生物系终身教授，是改革开放后哈佛大学引进的第一位来自中国大陆的终身教授；2009年担任哈佛大学Mallinckrodt讲席教授；2010年主持创办北京大学生物动态光学成像中心，担任主任；2016年组建北京大学未来基因诊断高精尖创新中心，担任主任；2017年当选为中国科学院外籍院士；2018年7月正式全职回到北京大学工作，并担任北京大学生物医学前沿创新中心主任；2020年担任北京昌平实验室主任；2023年6月由中国科学院外籍院士转为中国科学院院士。谢晓亮的主要研究方向包含：基础研究、技术开发和医学研究三个领域。基础研究：单分子酶学、单分子生物物理化学、基因表达和调控、表观遗传学、细胞分化和重编程机理、基因组不稳定性；技术发展：单分子成像、单细胞基因组学、相干拉曼散射显微成像、DNA测序；医学研究：体外受精胚胎植入前遗传学筛查与诊断、早期癌症诊断，新冠中和抗体药物研发。

谢晓亮是单分子酶学的创始人、单分子生物物理化学的奠基人之一、相干拉曼散射显微成像技术和单细胞基因组学的开拓者。谢晓亮作为单分子生物物理化学家，他勇于突破学科界限，从物理化学、生物物理到生物化学，再到分子生物学、基因组学及临床医学，无畏探索，不断创新，在相关新兴交叉学科做出了创造性贡献。

谢晓亮不仅是生物物理化学基础科学研究的国际领军人物，近年来大力推动了无标记光学成像技术和新型单细胞基因组测序技术在医学中的应用。2012年谢晓亮在单细胞全基因组学研究有了突破性进展，开发了单细胞全基因组均匀扩增的新方法—多重退火循环扩增法（MALBAC）。2014年9月19日，世界上第一例“MALBAC婴儿”在北医三院诞生，标志着中国胚胎植入前遗传诊断技术处于世界领先水平。

在抗击新冠疫情过程中，谢晓亮团队成功研制出一组针对所有新冠病毒变种的广谱中和抗体药物SA55/SA58，并已将其授权转让给科兴生物公司。

研究领域

谢晓亮课题组的研究方向包含基础科学研究领域、技术研究领域和医学研究领域三个领域。

领域	说明
基础研究	单分子酶学、单分子生物物理化学、基因表达和调控、表观遗传学、细胞分化和重编程机理、基因组不稳定性
技术发展	单分子成像、单细胞基因组学、相干拉曼散射显微成像、DNA 测序
医学研究	体外受精胚胎植入前遗传学筛查与诊断、早期癌症诊断

学术论著

截至2023年1月，谢晓亮共发表SCI收录科学论文240余篇。

Single Molecule Spectroscopy and Imaging

Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics" Science 265: 361-364 (1994).

Sánchez, Erik J; Novotny, Lukas; Xie, X. Sunney. "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips" Phys Rev Lett 82: 4014-4017 (1999).

Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney. "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy" Nature 461: 1105-1109 (2009).

Chong, Shasha; Min, Wei; Xie, X. Sunney. "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature" J Phys Chem Lett 1:3316-3322 (2010).

Zhou, Yuexin; Wang, Ping; Tang, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney “Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging”, Cell Research, doi:10.1038/cr.2017.9 (2017).

Single Molecule Enzymology

Lu, H. Peter; Xun, Luying; Xie, X. Sunney. "Single-Molecule Enzymatic Dynamics" Science 282: 1877-1882 (1998).

Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney. "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer" Science 302: 262-266 (2003).

Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney. "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule" Phys Rev Lett 94: 198302(1-4) (2005).

English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney. "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited" Nat Chem Bio 2: 87-94 (2006).

Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney. "Nonspecifically Bound Proteins Spin While Diffusing Along DNA" Nat Struct Mol Biol 16: 1224-1229 (2009).

Kim, Sangjin; Brostr?mer, Erik, Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao, Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. “Probing Allostery Through DNA” Science 339: 816-819 (2013).

Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).

Gene Expression and Regulation

Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney. "Probing Gene Expression in Live Cells, One Protein Molecule at a Time" Science 311: 1600-1603 (2006).

Cai, Long; Friedman, Nir; Xie, X. Sunney. "Stochastic Protein Expression in Individual Cells at the Single Molecule Level" Nature 440: 358-362 (2006).

Elf, Johan; Li, Gene-Wei; Xie, X. Sunney. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" Science 316: 1191-1194 (2007).

Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" Science 322: 442-446 (2008).

Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney. "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science 329: 533-538 (2010).

Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).

Ge, Hao; Qian, Hong; and Xie, X. Sunney. "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching" Phys Rev Lett 114(7) (2015).

Coherent Raman Microscopy

Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney. “Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering" Phys Rev Lett 82: 4142-4145 (1999).

Evans, Conor L.; Potma, Eric O.; Puoris'haag, Mehron; C?té, Daniel; Lin, Charles P.; Xie, X. Sunney. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102: 16807-16812 (2005).

Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney. "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy" Science 322:1857-1860 (2008).

Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering" Science 330: 1368-1370 (2010).

Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney. "RNAi Screening for Fat Regulatory Genes with SRS Microscopy" Nat Methods 8: 135-138 (2011).

Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney. "Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering" Nat Chem 6: 614-622 (2014).

Single Cell Genomics

Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338: 1622-1626 (2012).

Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing" Science 338: 1627-1630 (2012).

Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes" Cell 155: 1492-1506 (2013).

Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney "Live Births after Simultaneous Avoidance of Monogenic Diseases and Chromosome Abnormality by Next-generation Sequencing with Linkage Analyses," Proc Natl Acad Sci USA, 112(52), 15964-15969, (2015).

Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 (2017).

COVID-19

Cao, Yunlong; Jian, Fanchong; Wang, Jing; Yu, Yuanling; Song, Weiliang; Yisimayi, Ayijiang; Wang, Jing; An, Ran; Chen, Xiaosu; Zhang, Na; Wang, Yao; Wang, Peng; Zhao, Lijuan; Sun, Haiyan; Yu, Lingling; Yang, Sijie; Xiao, Tianhe; Gu, Qingqing; Shao, Fei; Hao, Xiaohua; Xu, Yanli; Jin, Ronghua; Shen, Zhongyang; Wang, Youchun; Xie, Xiaoliang Sunney "Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution," Nature (2022)

Cao, Yunlong; Jian, Fanchong; Zhang, Zhiying; Yisimayi, Ayijiang; Hao, Xiaohua; Bao, Linlin; Yuan, Fei; Yu, Yuanling; Du, Shuo; Wang, Jing; Xiao, Tianhe; Song, Weiliang; Zhang, Ying; Liu, Pulan; An, Ran; Wang, Peng; Wang, Yao; Yang, Sijie; Niu, Xiao; Zhang, Yuhang; Gu, Qingqing; Shao, Fei; Hu, Yaling; Yin, Weidong; Zheng, Aihua; Wang, Youchun; Qin, Chuan; Jin, Ronghua; Xiao, Junyu; Xie, Xiaoliang Sunney "Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents," Cell Reports (2022)

Cao, Yunlong; Song, Weiliang; Wang, Lei; Liu, Pan; Yue, Can; Jian, Fanchong; Yu, Yuanling; Wang, Yao; Yisimayi, Ayijiang; Wang, Peng; Wang, Yao; Zhu, Qianhui; Deng, Jie; Fu, Wangjun; Yu, Ling; Zhang, Na; Wang, Jing; Xiao, Tianhe; An, Ran; Wang, Jing; Liu, Lu; Yang, Sijie; Niu, Xiao; Gu, Qingqing; Shao, Fei; Hao, Xiaohua; Meng, Bo; Gupta, Ravindra Kumar; Jin, Ronghua; Wang, Youchun; Xie, Xiaoliang Sunney; Wang, Xiangxi "Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75," Cell Host & Microbe 30(11), 1527-1539 (2022)

Jian, Fanchong; Yu, Yuanling; Song, Weiliang; Yisimayi, Ayijiang; Yu, Lingling; Gao, Yuxue; Zhang, Na; Wang, Yao; Shao, Fei; Hao, Xiaohua; Xu, Yanli; Jin, Ronghua; Wang, Youchun; Xie, X. Sunney; Cao, Yunlong "Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants," Lancet Infect Dis (2022)

Cao, Yunlong; Yisimayi, Ayijiang; Jian, Fanchong; Song, Weiliang; Xiao, Tianhe; Wang, Lei; Du, Shuo; Wang, Jing; Wang, Jing; Li, Qianqian; Chen, Xiaosu; Yu, Yuanling; Wang, Peng; Zhang, Zhiying; Liu, Pulan; An, Ran; Hao, Xiaohua; Wang, Yao; Wang, Jing; Feng, Rui; Sun, Haiyan; Zhao, Lijuan; Zhang, Wen; Zhao, Dong; Zheng, Jiang; Yu, Lingling; Li, Can; Zhang, Na; Wang, Rui; Niu, Xiao; Yang, Sijie; Song, Xuetao; Chai, Yangyang; He, Ye; Shi, Yansong; Zheng, Linlin; Li, Zhiqiang; Gu, Qingqing; Shao, Fei; Huang, Weijin; Jin, Ronghua; Shen, Zhongyang; Wang, Youchun; Wang, Xiangxi; Xiao, Junyu; Xie, Xiaoliang Sunney "BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection," Nature 608, 593-602 (2022)

Cao, Yunlong; Hao, Xiaohua; Wang, Xi; Wu, Qianhui; Song, Rui; Zhao, Dong; Song, Weiliang; Wang, Yao; Yisimayi, Ayijiang; Wang, Wei; Zhang, Wen; Du, Juan; Yu, Hongjie; Xie, Xiaoliang Sunney; Jin, Ronghua "Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine," Cell Research 32, 107-109 (2022)

Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yasimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 (2021)

Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants," Cell Research 31, 1130–1133 (2021)

Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Ma, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines," Cell Research 31(7), 732-741 (2021)

Du, Shuo; Cao, Yunlong; Zhu, Qinyu; YU, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Liu, Jiangning; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan "Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy," Cell 183(4), 1013-1023.e13 (2020)

Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiaodong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells," Cell 182(1), 73-84.e16 (2020)

Key Review Articles

Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney. "Coherent Nonlinear Optical Imaging: beyond Fluorescence Microscopy" Annu. Rev. Phys. Chem. 62: 507-530 (2011).

Li, Gene-Wei; Xie, X. Sunney. "Central Dogma at the Single-Molecule Level in Living Cells" Nature 475: 308-315 (2011).

Xie, X. Sunney. "Enzyme Kinetics, Past and Present" Science 342: 1457-1459 (2013).

Xie, X. Sunney. "Single Molecules Meet Genomics: Pinpointing Precision Medicine" JAMA 20: 2021-2 (2015).

Huang Lei; Ma Fei; Chapman Alec; Lu Sijia; Xie X. Sunney. “Single-Cell Whole-Genome Amplification and Sequencing” Annu. Rev. Genomics Hum. Genet. 16: 79-102 (2015).

Cheng, Ji-xin; Xie, X. Sunney. “Vibrational Spectroscopic Imaging of Living Systems: An Emerging Platform for Biology and Medicine” Science 350, aaa8870 (2015).

人才培养

学子归来齐聚哈佛（2012）

1999年，谢晓亮进入哈佛大学任教来，培养了多名博士和博士后，截止到2017年，他所培养的学生在世界四十多所大学任教，其中一些学生的具体信息如下：

Graduate Students
Srinjan Basu	2006-2012	Cambridge University
Paul Blainey	2001-2007	Assistant Professor, Department of Biological Engineering, MIT, Broad Institute
Long Cai	2001-2006	Assistant Professor of Chemistry, CalTech
Chongyi Chen	2009-2014	Harvard Univerisity, Cambridge, Massachusetts
Huiyi Chen	2006-2011	Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore
Paul J. Choi	2005-2009	Senior Research Scientist , Genome Institute of Singapore
Shasha Chong	2009-2014	Department of Molecular & Cell Biology, University of California, Berkeley, California
Brian English	2001-2007	Albert Einstein College of Medicine
Conor Evans	2002-2007	Assistant Professor, Harvard Medical School
Christian Freudiger	2007-2011	CTO and Cofounder, Invenio Imaging
Sangjin Kim	2004-2010	Department of Molecular, Cellular & Developmental Biology, Yale University
John Krug	1998-2004	Roche
Gene-Wei Li	2005-2010	University of California, San Francisco
Sijia Lu	2008-2012	CTO and Cofounder, Yikon Genomics, Taizhou, China
Guobin Luo	2000-2006	Life Technologies
Wei Min	2001-2007	Assistant Professor, Columbia University
Xiaolin Nan	2001-2007	Assistant Professor, Oregon Health Science University
Brian Saar	2005-2010	Lincoln Laboratory, Massachusetts Institute of Technology
ErikSánchez	1995-1999	Assistant Professor, Portland State University
Peter Sims	2005-2009	Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center
Zi Hertz He	2011-2014	Bloomberg L.P., London
Ziqing Winston Zhao	2009-2015	Postdoc, Institute for Molecular and Cell Biology (IMCB), Singapore
Xu Zhang	2010-2015	Postdoctoral Fellow, Harvard University
Wenlong Yang	2011-2017	Postdoctoral Fellow, Harvard University
Postdoctoral Fellows
Dr. David Arnett	1998-1999	Associate Professor, Northwestern College, Iowa
Dr. Lewis Book	2000-2001	Northrop Grumman Space Technology, California
Dr. Erik Brostromer	2010-2011
Dr. Silvia Carrasco	2005-2006	Knowledge and Technology Transfer (KTT) director, ICFO
Dr. Huiyi Chen	2011-2012	Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore
Dr. Peng Chen	2004-2005	Peter Debye Professor of Chemistry, Cornell University, Deptartment of Chemistry and Chemical Biology
Dr. Ji-Xin Cheng	2000-2003	Professor, Purdue University, Weldon School of Biomedical Engineering
Dr. James Chesko	1997	Novartis Vaccines and Diagnostics, Emeryville, California
Dr. Jonathan Choi	1999-2000
Dr. Paul J. Choi	2009-2010	Senior Research Scientist , Genome Institute of Singapore
Dr. Robert A. Crowell	1994-1995	Brookhaven National Laboratory
Dr. Haifeng Duan	2009-2011	Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Dr. Xiaojie Duan	2007-2008	Assistant Professor, Peking University
Dr. Robert C. Dunn	1992-1995	Professor of Chemistry, University of Kansas
Dr. Johan Elf	2005-2007	Associate Professor in Molecular Biotechnology, University of Uppsala, Sweden
Dr. Wagner Faustino	2008-2010	Adjunct Professor, Federal University of Paraiba, Brazil
Dr. Kevin Fiala	2007-2009	MIT, Office of Technology Development
Dr. Christian Freudiger	2011-2013	CTO and Cofounder, Invenio Imaging
Dr. Nir Friedman	2003-2007	Weizmann Institute, Israel
Dr. Marcel Friedrich	2007-2008	Siemens Management Consulting, Munich, Germany
Dr. Feruz Ganikhanov	2004-2006	Assistant Professor, West Virginia University
Dr. Christof Gebhardt	2010-2013	Deputy Head, Institute of Biophysics, Ulm University, Germany
Dr. William Greenleaf	2008-2011	Assistant Professor, Genetics Dept., Stanford University School of Medicine
Dr. Terumasa Ito	2011-2012	Sony Coporation Research & Development
Dr. Minbiao Ji	2011-2014	Professor, Department of Physics, Fudan University, Shanghai, China
Dr. Lingjie Kong	2012-2013	Janelia Farm Research Campus, Virginia
Dr. Kang Taek Lee	2003-2004	Assistant Professor, Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Korea
Dr. Nam Ki Lee	2006-2009	Assistant Professor, Pohang University of Science and Technology, S. Korea
Dr. Gene-Wei Li	2010	UCSF
Dr. Jeff Li	2002-2008	Massachusetts Institute of Technology
Dr. Giuseppe Lia	2006-2009	CNRS, Centre de Genetique Moleculaire, Paris
Dr. Hong Peter Lu	1995-1999	Professor, Ohio Eminent Scholar, Bowling Green State University
Dr. Guobin Luo	2006-2008	Life Technologies
Dr. Yuntao Steve Mao	2011-2012	Scientific Editor, Cell, Cell Press, Cambridge
Dr. Wei Min	2008-2010	Assistant Professor, Columbia University, Department of Chemistry
Dr. Lukas Novotny	1996-1999	Professor, ETH Zürich
Dr. Antoine van Oijen	2001-2004	Professor, University of Wollongong, Australia
Dr. Pavel Pospisil	2001-2002	Palacky University, Czech Republic, Department of Experimental Physics
Dr. Eric Potma	2001-2005	Associate Professor, University of California at Irvine, Department of Chemistry
Dr. Maarten Roeffaers	2009-2010	Assistant Professor, Katholieke Universiteit Leuven
Dr. Rahul Roy	2007-2012	Assistant Professor, Indian Institute of Science, Department of Chemical Engineering, Bangalore, India
Dr. Markus Rueckel	2007-2008	BASF, Germany
Dr. Erik Sánchez	1999-2002	Assistant Professor of Physics, Portland State University
Dr. Ahbijit Sarkar	2002-2003	Assistant Professor, Dept. of Chemistry & Physics, Virginia State University
Dr. Charles Schroeder	2004-2007	Assistant Professor, University of Illinois, Urbana-Champaign, Department of Biomolecular Engineering
Dr. Katsuyuki Shiroguchi	2009-2012	Laboratory Leader, RIKEN Research Center for Allergy & Immunology, Laboratory for Integrative Genomics
Dr. Peter Sims	2009-2011	Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center
Dr. Hongye Sun	2000-2002	Vice President of Operation and Technology Platform, Chief Operating Officer, WuXi Genomic Center, WuXi AppTec, Shanghai
Dr. David Suter	2011-2013	Assistant Professor, School of Life Sciences, EPFL, Switzerland
Dr. Yuichi Taniguchi	2006-2011	Unit Leader, Quantitative Biology Center, RIKEN, Japan
Dr. Andreas Volkmer	1999-2001	University of Stuttgart, Germany, Institute of Physics
Dr. David Ward	2005-2007	President and Chairman, Piffany, Inc.
Dr. Jie Xiao	2002-2006	Assistant Professor, Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry
Dr. Haw Yang	2000-2002	Associate Professor of Chemistry, Princeton University
Dr. Wei Yuan Yang	2005-2007	Researcher, Academia Sinica, Taiwan, Institute of Biological Chemistry
Dr. Jun Yong	2011-2013	Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Dr. Ji Yu	2002-2006	Assistant Professor of Genetics and Developmental Biology, University of Connecticut Health Center
Dr. Guoqing Zhang	2010-2011	Assistant Professor, University of Science and Technology of China, School of Chemistry and Materials Science
Dr. Chenghang Zong	2009-2013	Assistant Professor, Department of Molecular and Human Genetics. Baylor College of Medicine
Dr. Andreas Zumbusch	1997-1999	Professor of Physical Chemistry, Universität Konstanz, Germany
Dr. Yan Gu	2013-2014	Scientist at Bristol-Myers Squibb
Dr. Dan Fu	2010-2015	Assistant Professor, Department of Chemistry, University of Washington
Dr. Xiaohui Ni	2011-2015	Cynvenio Biosystems, California
Dr. Yi Yin	2015-2016	Postdoc, University of Washington
Dr. Haisong Liu	2014-2016	Postdoctoral Fellow, Salk Institute
Dr. Asaf Tal	2015-2017
Dr. Fa-Ke Frank Lu	2011-2017	Assistant Professor, Department of Biomedical Engineering, Binghamton University, State University of New York
Dr. Sabin Mulepati	2014-2017	Intellia Therapeutics, Massachusetts
Visiting Scholars
Prof. Jianming Li	2011	Southern Medical University, China
Prof. Biman Bagchi	2007	Indian Institute of Science
Prof. Paul Champion	2002-2003	Department of Physics, Northeastern University
Prof. Binny Cherayil	2004-2005	Department of Inorganic and Physical Chemistry, Indian Institute of Science
Prof. Nai-Ho Cheung	2000-2001	Department of Physics, Hong Kong Baptist University
Dr. Peijun Cong	2010	Invenio Imaging
Dr. Mircea Cotlet	2003	Brookhaven National Laboratory, Center for Functional Nanomaterials
Prof. Hao Ge	2010-2011	Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Prof. Casey Hynes	2011	Department of Molecular Biophysics, University of Colorado, Boulder
Prof. Carey Johnson	1997	Department of Chemistry, University of Kansas
Dr. Laura Kaufman	2002-2004	Department of Chemistry, Columbia University
Dr. Francois Legare	2004-2006	INRS-EMT, Université du Québec, Varennes, Canada
Prof. Peter Leung	1995	Department of Physics, Portland State University
Prof. Yuanzong Li	2002-2003	College of Chemistry and Molecular Engineering, Peking University, China
Prof. Vahid Sandoghdar	2009	Department of Chemistry, Swiss Federal Institute of Technology, Switzerland
Prof. Andrei Tokmakoff	2005-2006	Department of Chemistry, Massachusetts Institute of Technology
Dr. Martin Vogel	2006-2008	Max Planck Institute of Biophysics, Department of Molecular Neurogenetics
Prof. Nils Walter	2006	Department of Chemistry, University of Michigan
Prof. Xinhua Wan	2004-2005	College of Chemistry and Molecular Engineering, Peking University, China
Prof. Peng-Ye Wang	2010	Institute of Physics, Chinese Academy of Sciences
Prof. Luying Xun	2004-2005	School of Molecular Biosciences, Washington State University
Prof. Xinsheng Zhao	2003	College of Chemistry and Molecular Engineering, Peking University, China
Prof. Zemin Yao	2014-2015	Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Canada
Yuanzhen Suo	2015-2017	Shanghai Jiao Tong University
Shufang Wang	2016-2017	Chinese PLA General Hospital

荣誉表彰

时间	奖项/荣誉	授予单位
2021年度	北京市科学技术奖突出贡献中关村奖	北京市人民政府
2017年12月	2017年度中国留学人员50人榜单
2017年11月	中国科学院外籍院士	中国科学院
2017年9月	求是杰出科学家奖	香港求是基金会
2016年10月	美国国家医学院院士	美国国家医学院
2016年	吴瑞奖	华人生物学家协会
2015年	贝时璋奖	中国生物物理学会
2015年	阿尔伯尼生物医学奖（Albany）	纽约州阿尔巴尼医学中心
2015年	Peter Debye物理化学奖	美国化学会
2014年	美国光学会会士	美国光学会
2014年	德国洪堡学者
2013年	美国NIH Director's Pioneer Award
2013年	Ellis R. Lippincott奖	美国光学学会及应用光谱学会
2012年	Harrison Howe奖	美国化学会Rochester分部
2012年	美国微生物学会会士	美国微生物学会
2012年	Founders奖	美国生物物理学会
2011年5月3日	美国国家科学院院士	美国国家科学院
2010年	中国化学会荣誉会士	中国化学会
2009年	欧内斯特·奥兰多·劳伦斯奖（化学类）	美国能源部
2008年	美国物理学会会士	美国物理学会
2008年	美国艺术与科学学院院士	美国艺术与科学学院
2008年	Berthold Leibinger Zukunftspreis激光技术奖
2007年	Willis E.Lamb激光科学与量子光学奖
2006年	美国科学促进会会士	美国科学促进会
2006年	美国生物物理学会会士	美国生物物理学会
2004年	美国NIH Director's Pioneer Award
2003年	以色列Raymond and Beverly Sackler 物理科学奖
2003年	Hoope奖	哈佛大学
2003年	Joe Markson优秀本科毕业论文指导教师
1996年	Coblentz奖

社会任职

编辑

任职时间	担任职务
2023年	第十四届全国政协委员、常委、教科卫体委员会委员
2009年—2011年	《科学（Science）》编委
2004年—	国家纳米科学中心学术委员会委员（第一届、第二届）
2002年—2007年	《物理化学年度评论（Annual Review of Physical Chemistry）》编委
2001年—2006年	《化学研究述评（Accounts of Chemical Research）》编委
2001年—2009年	中国科学院化学研究所分子动态与稳态结构国家重点实验室学术委员会委员（第五届）
2001年—	《化学物理（Chemical Physics）》编委
2001年—	《化学物理学报（Chemical Physics Letters）》编委
2000年—	《化学物理化学（Chem. Phys. Chem.）》编委
2000年—2008年	《物理化学杂志（Journal of Physical Chemistry ）》编委
2000年—2001年	《生物物理学杂志（Biophysical Journal）》编委
1999年—2007年	《显微镜技术杂志（Journal Of Microscopy）》编委
1999年—2002年	《单分子（Single Molecules）》编委
	《物理化学学报》编委

个人生活

编辑

家世背景

谢晓亮的父亲谢有畅与母亲杨骏英皆为北京大学化学系的教授。

人物评价

编辑

谢晓亮在非线性拉曼显微学和高灵敏度分子振动成像领域具有创新研究，在创立单分子生物物理化学领域中处于科学领导地位，而且他在酶反应动力学和活细胞基因表达领域做出了杰出工作。（2009年美国欧内斯特·奥兰多·劳伦斯奖）

谢晓亮是单细胞生物学领域的领军人物，他已在该领域做出了关于单个分子及其行为影响细胞的生命过程乃至人类疾病的诸多研究成果。（2015年美国阿尔伯尼生物医学奖）

谢晓亮是学科交叉研究的践行者，从物理化学、生物物理到生物化学，再到分子生物学，基因组学及临床医学，他无畏探索，不断创新，他是单分子酶学的创始人、单分子生物物理化学的奠基人之一、相干拉曼散射显微成像技术和单细胞基因组学的开拓者，在单分子生物物理和生物医学光学成像领域作出了杰出的贡献。（2017年求是科学基金会评）

做事情就是要持之以恒，不要放弃，要坚持，要不怕困难的做下去，要有耐心，不要追求那种短期就能出成果的东西。谢晓亮常常会用4年甚至更长的时间来做一个研究，他发现自己做错的东西，也不放弃，重新开始做，所以，坚持是一个很重要的东西，是他获得成功肯定的一个很重要的元素，对我也意义重大。（美国国家科学院院士、哈佛大学教授庄小威）

谢晓亮的第一个基础研究工作是1998年开展的单分子酶学，他开创了在单分子层面对生命过程的研究。近年他又开始探探索在医学上的应用。中国引进现代医学后，在现代药学方面只有少数几个药物作用领域的发现，在现代医学技术上唯一的发明和应用就是谢晓亮和汤富酬、乔杰三个团队合作诞生的‘MALBAC婴儿’ 。（北京大学生命科学院饶毅）

谢晓亮的MALBAC技术能够改变整个生物医学，其对未来精准医学的发展和应用的贡献是不可限量的。“获得终身教授的人很多，但真正能够在人类历史上，特别是科技史上留下印记的科学家非常少见，而谢晓亮将理论和技术结合，用技术解决科学问题，是引领整个科学界发展的真正的一流科学家，他是一个让你无法预知将来还会做出什么创造性工作的科学家。这是一个科学家具有潜在创造力、影响力、引领力的标志。（中国医学科学院院长曹雪涛）

谢晓亮

1、本站所有文本、信息、视频文件等，仅代表本站观点或作者本人观点，请网友谨慎参考使用。
2、本站信息均为作者提供和网友推荐收集整理而来，仅供学习和研究使用。
3、对任何由于使用本站内容而引起的诉讼、纠纷，本站不承担任何责任。
4、如有侵犯你版权的，请来信（邮箱:baike52199@gmail.com）指出，核实后，本站将立即删除。

下一篇钱煦

上一篇前野悦辉